Fresh analysis reveals that people who stop using blockbuster GLP-1 drugs like Wegovy and Mounjaro may regain reduced body mass far faster than those who stop traditional diet and exercise plans.
Research printed in a leading health publication demonstrates that while overweight individuals can lose a large proportion of their body weight while undergoing treatment, the mass returns at an average rate of nearly a kilo each month upon discontinuation.
"Individuals using such drugs should be informed of the danger of quick rebound weight gain when the therapy is stopped," cautioned expert Dr. Susan Jebb.
This pace of regain implies a return to starting mass within about 18 months.
Comparing Treatments
The research, which reviewed 37 of studies involving over 9,000 of participants, contrasted the results of GLP-1 agonists with other pills.
Scientists point out that people who shed pounds through dieting generally see a more gradual creep back—approximately 100 grams monthly—once they finish.
Understanding the Fast Rebound
Nutrition scientists suggest the mode of action of the jabs explains the amplified regain.
The injections mimic a natural hormone called glucagon-like peptide-1, which moderates feelings of fullness.
"Artificially providing GLP-1 concentrations several times higher than the body's typical production may cause the body to produce less of its endogenous hormone, and could lessen sensitivity to its actions," noted Dr. Adam Collins, a dietetics specialist.
"Stopping of this hormone supplement leads to hunger is unsuppressed, making binge eating a significant risk."
A Chronic Disease?
The NHS suggest the injections for people with weight-linked medical conditions, alongside recommended lifestyle changes.
Professionals say that, considering the likelihood of relapse, the therapy is often ongoing.
This opinion is echoed by drug manufacturers, who state that the results "highlight the long-term character of excess weight," akin to managing diseases like high blood pressure.
User Experiences
Users who have stopped the medication report a powerful resurgence of appetite.
"It felt as if a trigger flipping and I was suddenly extremely hungry," said a patient.
This challenge is exacerbated if users have not adopted permanent dietary or behavioural changes during treatment.
Growing Use
Recent estimates indicate that a significant number of adults in the UK have tried these injections in the past year, with desire being substantial.
- Use is more common among females compared to males.
- The 40s and 50s demographic shows the highest usage rates.
- Many access the medications through private prescriptions rather than the NHS.
Ultimately, experts emphasize that while the jabs are powerful agents for shedding pounds, they are not a magic fix and lasting health benefits likely depends on ongoing behavioural changes.
